| 1657 | Boston | Measles |
| 1687 | Boston | Measles |
| 1690 | New York | Yellow Fever |
| 1713 | Boston | Measles |
| 1729 | Boston | Measles |
| 1732-3 | Worldwide | Influenza |
| 1738 | South Carolina | Smallpox |
| 1739-40 | Boston | Measles |
| 1747 | CT, NY, PA, SC | Measles |
| 1759 | N. America | Measles: areas inhabited by white people |
| 1761 | N. America and West Indies |
Influenza |
| 1772 | N. America | Measles |
| 1775 | N. America | Unknown epidemic: especially hard in NE |
| 1775-6 | Worldwide | Influenza: one of the worst epidemics |
| 1783 | Dover, DE | "Extremely fatal" bilious disorder |
| 1788 | Philadelphia and New York | Measles |
| 1793 | Vermont | A "putrid" fever and Influenza |
| 1793 | Virginia | Influenza: killed 500 in 5 counties in 4 weeks |
| 1793 | Philadelphia | Yellow Fever: one of the worst epidemics |
| 1793 | Harrisburg, PA | Many unexplained deaths |
| 1793 | Middletown, PA | Many unexplained deaths |
| 1794 | Philadelphia, PA | Yellow Fever |
| 1796-7 | Philadelphia, PA | Yellow Fever |
| 1798 | Philadelphia, PA | Yellow Fever: one of the worst |
| 1803 | New York | Yellow Fever |
| 1820-3 | Nationwide | "Fever" - started Schuylkill River and spread |
| 1831-2 | Nationwide | Asiatic Cholera: brought by English emigrants |
| 1832 | NY City and other major cities | Cholera |
| 1833 | Columbus, OH | Cholera |
| 1834 | New York City | Cholera |
| 1837 | Philadelphia | Typhus |
| 1841 | Nationwide | Yellow Fever: especially severe in the south |
| 1847 | New Orleans | Yellow Fever |
| 1847-8 | Worldwide | Influenza |
| 1848-9 | North America | Cholera |
| 1849 | New York | Cholera |
| 1850 | Nationwide | Yellow Fever |
| 1850 | Alabama, New York | Cholera |
| 1850-1 | North America | Influenza |
| 1851 | Coles Co., IL, The Great Plains, and Missouri |
Cholera |
| 1852 | Nationwide | Yellow Fever: 8,000 die in New Orleans |
| 1855 | Nationwide | Yellow Fever |
| 1857-9 | Worldwide | Influenza: one of the greatest epidemics |
| 1860-1 | Pennsylvania | Smallpox |
| 1865-73 | Philadelphia, NY, Boston, New Orleans, Baltimore, Memphis, Washington DC |
Smallpox, Cholera :A series of recurring epidemics of, Typhus, Typhoid, Scarlet Fever, Yellow Fever |
| 1873-5 | N. America and Europe | Influenza |
| 1878 | New Orleans | Yellow Fever: last great epidemic |
| 1885 | Plymouth, PA | Typhoid |
| 1886 | Jacksonville, FL | Yellow Fever |
| 1918 | Worldwide | high point yr... Influenza: more people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps |
 | Ripley County, INGenWeb Project -- Epidemics & Medical Terms(Terminology) -- |  |